• http://www.bowlabels.com/How to Make Wine Labels If you make your own wine, or simply want to spruce up a wine bottle for a party, you can make wine labels with two Microsoft programs: Microsoft Office and Microsoft Publisher. These programs allow you to customize your own wine labels with text and graphics. Impress your guests with your own bottle of wine customized to suit the theme of the party. Designing your own wine labels is simple after you familiarize yourself with the basics of these programs. Open the Microsoft Publisher Catalog. Choose "Labels" and then select "Borders Shipping Label." You will see a button that says "Start Wizard." Select this option, and then choose "Finish." Select the "Business Name" box and hit delete on your keyboard. You will also need to delete the line under the box, and the business logo. If you do not know where the delete button is on your keyboard, simply right-click on each object and select "Cut." Use the "Label Wizard" box on the left side of your screen. Choose the "Color Scheme" for your wine label. Choose the "Primary Business Address" box and change the text with the font options located on the tool bar. You can add any text in this box that you will want displayed on the wine label. Try changing the size, color and style of the text to suit the theme of your wine bottle. Once you change the text in the "Primary Business Address" box, select the "Mailing Address" box and elect to change the text. Use the "Text Frame" tool to add any additional text. Select each box and drag it to the center of your wine label. Insert a picture to your label by selecting the "Insert" menu, selecting "Picture" and clicking "Clip Art." In the search box you can look for clip art to match your wine bottle. Select the image you want, and click "Insert Clip Art." You can change the size of the clip art by dragging any of the corners to resize the image. Print the wine labels on sticker paper. Select "Print" from the "File Menu." Once the label prints, cut it out with scissors and stick it on to your bottle. Make Wine Labels with Microsoft Word Step 1 Open a new document in Microsoft Word. When the "New Document" window opens, select "Labels" on the left side of the box and choose "Mailing and Shipping" and then click "Business Labels." Select the appropriate size label for your wine bottle. Step 2 Highlight the text on each label and hit the backspace or delete button on the keyboard. Use the "Tool Bar" to add your own text. You can experiment with the size, color and font style of your text. Step 3 Choose the "Insert" tab located on the toolbar. Select to insert a "Picture" or "Clip Art." When you select to insert a picture, you will need to locate it on your computer. Once you select to insert clip art, a search box will appear on the right side of the screen. Type any keywords to find the appropriate clip art for the wine label. Step 4 Use the "Insert" tab to add more details to your wine label. You can add another text box, draw a shape and even add a border and background color to your label. Step 5 Select "Print" from the "File Menu." Select "Properties" and ensure that you print the label in the highest quality. Once the label prints, cut it out with scissors and stick it onto your wine bottle. Automated Data Labeling vs Manual Data Labeling: Optimizing Annotation Accurately labeled datasets are the raw material for the machine and deep learning revolution. Vast quantities of data are required to train new generations of Artificial Intelligence (AI). Correctly labelled images train AI systems to reliably distinguish between a stop sign and pedestrian or between a raised hand and a raised gun. Demand for data labeling for vision-based machine learning is therefore growing rapidly. AI developers increasingly need larger training datasets that maintain the accuracy that is so vital for safety and reliability. How do we go about creating the accurate, scalable datasets that industry needs? To begin answering this question we first need to consider automated data labeling vs manual data labeling. The differences between these approaches to data labeling point the way forward for smart dataset creation. Automatic Data Labeling: Machines Training Machines Automatic data labeling processes have the potential to overcome some of the challenges presented by the laborious annotation cycle. After training from a labeled dataset, a machine learning model can be applied to a set of unlabeled data. The model should then be able predict the appropriate labels for the new dataset. Automated data labeling algorithms can be improved via human input. After the AI has labeled the raw data, a human annotator reviews and verifies the labels. Accurately labeled data can then take its place in the training dataset. If the annotator observes mistakes in the labeling they can then proceed to correct it. This corrected data can then also be used to train the labeling AI. The Auto-label AI is capable of handling the majority of easily identified labels. This has the advantage of greatly speeding up the initial labeling stage. However, automated data labeling still produces a significant amount of errors that could prove costly when fed through to an AI model. Manual Data Labeling: The Human Touch Manual data labeling generally means individual annotators identifying objects in images or video frames. These annotators comb through hundreds of thousands of images hoping to construct comprehensive, quality AI training data. Specific labeling techniques are applied to the raw data depending on the needs of the developer. These techniques include: Bounding box annotation: A rectangle is drawn around the object in the image allowing an AI to recognise/avoid it. This technique is more common due to its relative simplicity and is therefore more cost effective. Polygon annotation: In this case the annotator is required to plot vertices around an object in order to more accurately capture its shape. Semantic segmentation: This is a technique used for grouping together objects in an image e.g. separating roads from buildings. This type of labeling is more precise and therefore more difficult. Manual data labeling has the potential to be somewhat labour intensive. Each instance of labeling may take seconds but the multiplicative effect of thousands of images could create a backlog and impede a project. This is why many AI developers are opting to use professional data annotation services, such as Keymakr, to produce their machine learning datasets. A managed workforce of experienced annotators is able to scale manual data labeling to the demands of any project. Significant advancements have been made with automated labeling algorithms. However, well-trained human annotators remain the go-to when it comes to precision and quality in training datasets. Manual labeling is able to capture the edge cases that automated systems continue to miss, and knowledgeable human managers are able to ensure quality across huge volumes of data. Requirements for the Art merit badge: Discuss the following with your counselor: What art is and what some of the different forms of art are The importance of art to humankind What art means to you and how art can make you feel Discuss with your counselor the following terms and elements of art: line, value, shape, form, space, color, and texture. Show examples of each element. Discuss with your counselor the six principles of design: rhythm, balance, proportion, variety, emphasis, and unity. Render a subject of your choice in FOUR of these ways: Pen and ink, Watercolors, Pencil, Pastels, Oil paints, Tempera, Acrylics, Charcoal Computer drawing or painting Do ONE of the following: Design something useful. Make a sketch or model of your design. With your counselor's approval, create a promotional piece for the item using a picture or pictures. Tell a story with a picture or pictures or using a 3-D rendering. Design a logo. Share your design with your counselor and explain the significance of your logo. Then, with your parent's permission and your counselor's approval, put your logo on Scout equipment, furniture, ceramics, or fabric. With your parent's permission and your counselor's approval, visit a museum, art exhibit, art gallery, artists' co-op, or artist's workshop. Find out about the art displayed or created there. Discuss what you learn with your counselor. Find out about three career opportunities in art. Pick one and find out the education, training, and experience required for this profession. Discuss this with your counselor, and explain why this profession might interest you. posted an update 5개월전

    http://www.yycindustry.com/Steroids: Do They Work and Are They Safe?
    “Legal steroids” is a catch-all term for muscle-building supplements that don’t fall under the category of “illegal.”

    Anabolic-androgenic steroids (AAS) are synthetic (manufactured) versions of the male sex hormone testosterone. These are sometimes used illegally.

    People who have muscle wasting or testosterone production disorders can take these hormone supplements for their condition if prescribed by a healthcare provider.

    However, some athletes and bodybuilders illegally use these steroids to boost muscle mass or performance.

    Some legal supplements do have science on their side and aren’t entirely unsafe. But others may be completely ineffective or even cause harm.

    Creatine

    Creatine is one of the most well-known performance support options. It’s a naturally occurring substance found in foods like fish and meat. It’s also sold in many stores as a muscle-building supplement.

    Creatine has numerous documented benefits:

    A 1999 studyTrusted Source found that weightlifters who used creatine showed nearly three times as much growth in muscle fibers and doubled overall body mass than those who didn’t use creatine.

    A 2003 studyTrusted Source found that using creatine when you’re weight training can help build strength in your legs and increase your overall muscle mass.

    A 2007 reviewTrusted Source of muscle-building supplements indicated that creatine is the best supplement for increasing muscle mass.

    Research has also found no long-term health effects of using creatine.

    Look out for any extra ingredients in supplements that may have side effects or cause allergic reactions.

    Matrix metalloproteinase (MMP)

    MMP is a blend of creatine, betaine, and dendrobium extract that’s often sold as Craze or various other names.

    This supplement is relatively safe to use. However, it doesn’t result in the muscle-building claims this drug’s marketing copy might lead you to believe.

    A 2014 studyTrusted Source found that participants who used it for a 6-week training period reported higher energy and better concentration, but no increases in body mass or overall performance.

    As with other OTC supplements, look out for additional ingredients that can cause allergic reactions or long-term health effects.

    Dimethylamylamine (DMAA)

    DMAA has been found in numerous muscle-building and weight loss supplements, but it’s not safe. Any product that contains it and markets itself as a dietary supplement is illegal.

    The Food and Drug Administration (FDA)Trusted Source has released numerous warnings to consumers to steer clear of DMAA and its various forms in OTC supplements.

    Using DMAA can lead to one or more of the following complications:

    narrowing of blood vessels

    increased blood pressure

    shortness of breath

    feeling of chest tightness

    irregular heartbeat

    heart attack

    seizures

    neurological disorders

    mental health conditions

    Bodybuilder Injects Coconut Oil, Damages Arm Muscle
    Instead of just lifting weights, an amateur bodybuilder in the United Kingdom tried to plump up his arm muscles and by injecting them with

    Instead of just lifting weights, an amateur bodybuilder in the United Kingdom tried to plump up his arm muscles and by injecting them with coconut oil, according to a new report of the case.

    But he wound up developing cysts inside his arm muscles from the oil, and because he also used steroids, he ruptured his triceps and needed surgery, the report said.

    The 25-year-old-man first went to the doctor because his arm hurt and he had had trouble moving it for several months. He told the doctor that he had taken up bodybuilding four years earlier, and that he went to the gym three times a week.

    An ultrasound revealed a rupture in the tendon that connects the triceps muscle (in the upper arm) to the bone near the elbow. This type of injury is rare in young people, the report said. The ultrasound also showed multiple cysts inside his arm muscle.

    From these findings, the man’s doctors suspected that he might be injecting substances into his arm. When he was asked about this, the patient admitted that he had injected coconut oil into his arm muscles to increase their size and definition.

    Although anabolic steroids are perhaps the most well-known substances that bodybuilders inject to bulk up muscle, they also sometimes inject other substances, including natural oils — like sesame oil, walnut oil and paraffin — to make their muscles appear to be larger, the report said. Natural oils are less expensive than anabolic steroids, which may make them an attractive option, particularly for amateur bodybuilders, the report said.

    “Alarmingly, this practice, used for the short-term enhancement of muscular appearance, seems to come at a significant cost,” the man’s doctors, from London North West Healthcare NHS Trust health system, wrote in the Dec. 1 issue of the journal BMJ Case Reports. In an earlier case, a bodybuilder in Germany who injected sesame seed oil into his muscles for eight years experienced scarring and deformity in his muscle tissue, and had irreversible muscle damage that prevented him from weightlifting normally.

    Other side effects of similar injections include skin sores, infection and potentially life-threatening blockages of blood vessels, due to the globbing up of the fat in the oils, the report said.

    A review of the U.K. man’s medical history also revealed that he had engaged in several other problematic practices in order to bulk up his muscles. For example, he had used insulin without a prescription, which caused him to have seizures. He had also injected himself with vitamin B12, which resulted in a bacterial infection. And he had used anabolic steroids, which caused him to develop swollen breast tissue and benign tumors on his liver — and both conditions required surgery.

    It’s likely that the man’s triceps tendon rupture resulted from his use of anabolic steroids, which led to stiffening of the tendon and rupture after repeated weightlifting, the report said.

    The man underwent surgery to repair his tendon, which healed well. But he continued to practice unsafe bodybuilding techniques to maintain his desired body image, despite being counseled about the risks of those practices, the report said.

    “[Doctors] need to be aware of these cases,” so that they can diagnose patients correctly and recognize potentially life-threatening practices among bodybuilders, the report said.

    Natural and Pharmaceutical Estrogen Blockers for Men
    These natural products may help block estrogen:

    Wild nettle root: Nettle root or nettle leaves are often used to make prostate medication. Nettles contain compounds that act as natural estrogen blockers. Taking supplements can regulate production of the hormone.

    Chrysin: This flavonoid is found in passionflower, honey, and bee propolis. Proponents argue that it blocks estrogen and increases testosterone, and others claim that there’s no evidence.

    Maca: Maca is a cruciferous plant that originates in Peru. Proponents say it has a host of benefits, including enhancing fertility and blocking estrogen in men. Although

    macaTrusted Source
    does contain many vitamins and nutrients, there’s little scientific evidence that it plays a role in regulating hormones.

    Grape seed extract: This extract has been shown to act as an aromatase inhibitor, or estrogen blocker, in postmenopausal women at high risk for breast cancer. Men may experience similar benefits when taking it as a supplement.

    Local Anesthetics
    Local anesthetics produce anesthesia by inhibiting excitation of nerve endings or by blocking conduction in peripheral nerves. Cocaine, a compound indigenous to the Andes Mountains, West Indies, and Java, was the first anesthetic to be discovered and is the only naturally occurring local anesthetic; all others are synthetically derived. Cocaine was introduced into Europe in the 1800s following its isolation from coca beans. Sigmund Freud, the noted Austrian psychoanalyst, used cocaine on his patients and became addicted through self-experimentation.

    In the latter half of the 1800s, interest in the drug became widespread, and many of cocaine’s pharmacologic actions and adverse effects were elucidated during this time. In the 1880s, Koller introduced cocaine to the field of ophthalmology, and Hall introduced it to dentistry

    Types of active pharmaceutical ingredients
    APIs are broadly categorised into two types – synthetic and natural. Synthetic APIs are further classified into innovative and generic synthetic APIs, based on the type of synthesis used.

    Synthetic chemical APIs, also known as small molecules, constitute a large part of the pharmaceutical market, with many small molecule drugs commercially available in the market.

    Natural APIs are used in making biologics, which are increasingly becoming the top-selling drugs in the market. Despite the growing demand, biologics are currently significantly fewer in number compared to small molecule drugs.

    Based on the solubility, APIs are categorised into insoluble and soluble drugs.

    Pharmaceutical Technology has listed the leading suppliers of active pharmaceutical ingredients and intermediates based on its intel, insights and decades-long experience in the sector. The list includes companies that can develop and supply high-quality pharmaceutical materials, including, but not limited to:

    Fine chemicals and intermediates, such as high-docosahexaenoic acid oil for API production

    APIs for central nervous system therapies

    Natural cannabinoid (CBD) ingredients, CBD isolates and cannabis distillates

    Excipients

    Insulin for cell culture media

    Ammonium compounds

    Mineral salts

    The list also includes suppliers of mixing and drying technologies, polymer coatings for drug delivery, extraction technologies for high-purity APIs, and dispersion and wet milling technology. Providers of automatic capsule filling machines, dry powder and liquid-based material handling systems, analytic services for biological assays, pharma tablet manufacturing machines, and custom synthesis services are detailed in the document as well.

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